Expert opinion: Sodium oxybate is an effective therapy for excessive daytime sleepiness and cataplexy in adults and children ages 7–17 years. The authors concluded that sodium oxybate significantly reduced cataplexy, significantly improved daytime sleepiness, and was well tolerated. of narcolepsy. Sodium oxybate promotes deep sleep and improves night-time sleep. It helps with EDS as well as helping to control cataplexy. Sodium oxybate is often thought of as the most effective treatment for narcolepsy with cataplexy, either on its own or in combination with one or more stimulants. However, not all patients find it beneficial. Oxybate is a small, neuroactive molecule (gamma-hydroxybutyrate) that is used to treat catalepse and daytime sleepiness in patients with narcolepsy. The efficacy of oral sodium oxybate on the treatment of narcolepsy was evaluated in two randomized, double-blind, placebo- controlled, multicenter, US 42 and International trials. A new lower-sodium product is the latest in a wave of novel therapies with differing mechanisms of action that are improving quality of life for people with narcolepsy and its associated symptoms. The FDA has approved two GHB formulations for treating narcolepsy. Sodium oxybate for the treatment of narcolepsy with cataplexy: An orphan drug for an orphan disease: What is narcolepsy? We aim to analyze the relation between sodium oxybate (SXB) treatment and psychotic symptoms in narcolepsy patients. Also known as: Xyrem Sodium oxybate has an average rating of 7.7 out of 10 from a total of 94 ratings for the treatment of Narcolepsy. Xyrem (sodium oxybate) oral solution is indicated for the treatment of cataplexy in narcolepsy. Xyrem (sodium oxybate) is the sodium salt of gamma-hydroxybutyrate (GHB) which is a central nervous system (CNS) depressant. Sodium oxybate is a central nervous system depressant. A low-sodium alternative to sodium oxybate, JPZ-258, is a recently developed mixed salts oxybate oral solution. Sleep Med 2015; 16:52. The sodium content of SO ranges from 550 to 1640 mg at 3-9 g, given in two equal nightly doses. In one of his articles, Sleep Review outlines that "for more than a decade and a half, Xyrem (Sodium Oxybate) has been prescribed to patients with narcolepsy who … For sodium oxybate, a 4-week crossover pilot study , and a 4-week DB parallel group RCT, testing three doses of 3, 6, and 9 g/d compared with placebo in 136 patients with narcolepsy (SX-US-2002) provided evidence of a beneficial effect of sodium oxybate in cataplexy and EDS with the highest dose (9 g/d), and on ESS with a lower dose (6 g/d). Xyrem is a central nervous system depressant (sedative). It is used to treat cataplexy (sudden loss of muscle strength) and reduce daytime sleepiness caused by narcolepsy in adults and children at least 7 years old. The nightly use of sodium oxybate is associated with a reduction in nocturnal sleep disruption: a double-blind, placebo-controlled study in patients with narcolepsy. But it's not yet funded by the NHS in many areas. Sodium oxybate has efficacy in many narcolepsy symptoms. Background and purpose: This study was conducted to demonstrate the long-term efficacy of sodium oxybate for the long-term treatment of cataplexy in patients with narcolepsy.. Sodium oxybate (SO), the sodium salt of γ-hydroxybutyric acid, is one of the primary pharmacologic agents used to treat excessive sleepiness, disturbed nighttime sleep, and cataplexy in narcolepsy. 1 How does Xyrem work? The prevalence of narcolepsy with cataplexy is … Xywav leverages other positively charged ions that “don’t have the negative effects of sodium” with oxybate, Iannone says, resulting in an oral solution with 92% less sodium than Xyrem. Prior use of sodium oxybate is allowed in the study but with the following exclusions: a. That formulation is indicated for twice-nightly administration, with the second dose taken 2.5 to 4 hours after the first. The study also found that patients on sodium oxybate experienced less work and activity impairment compared to those not taking sodium oxybate. In Narcolepsy With Cataplexy, a New Form of Sodium Oxybate Promises Better Long-Term Safety. Sodium oxybate (SO), the sodium salt of γ-hydroxybutyric acid, is one of the primary pharmacologic agents used to treat excessive sleepiness, disturbed nighttime sleep, and cataplexy in narcolepsy. Sodium oxybate is recognized as standard of care by the American Academy of Sleep Medicine for patients living with narcolepsy, a chronic neurological condition that impacts about 1 in 2,000 Americans. XYREM ® (sodium oxybate) oral solution, 0.5 g/mL is a prescription medicine used to treat the following symptoms in people 7 years of age or older with narcolepsy: sudden onset of weak or paralyzed muscles (cataplexy) excessive daytime sleepiness (EDS) Important Safety Information SXB was given in a regular starting dose of 2 nighttime doses of 2.25 grams. A novel, once-nightly formulation of sodium oxybate is safe and effective for treating both subjective and objective symptoms of narcolepsy, new research suggests. Cataplexy is found in 75% patients with narcolepsy [5]. Narcolepsy can occur in pre-pubertal children but post-pubertal cases are more common [4]. Almost all of the patients who received XYREM during clinical trials in narcolepsy were receiving CNS stimulants. DESCRIPTION. The authors noted that, in the patients who received placebo, cataplexy and sleep symptoms worsened significantly compared with the patients who received lower-sodium oxybate. Sodium oxybate is a central nervous system depressant. Sodium Oxybate(Oral) received an overall rating of 10 out of 10 stars from 1 reviews. Previous dosing must have been limited to no more than 4.5g per night; b. Sodium Oxybate Oral Solution is a central nervous system depressant indicated for the treatment of: • Cataplexy in narcolepsy (1.1). … Sodium oxybate therapy for narcolepsy can eat up a large chunk of the daily recommendation even before any food is consumed. The document aims to facilitate local decisions by a CCG on whether to commission sodium oxybate for use in all adult patients. 2 Epidemiology Narcolepsy is a lifelong disorder. In this study, we estimate the cost‐effectiveness of sodium oxybate as treatment for patients with narcolepsy as compared to standard treatment, by calculating incremental cost‐effectiveness ratios (cost per quality‐adjusted life year, QALY) for patients in a Swedish setting. Sodium oxybate is an effective drug for reducing cataplexy attacks and excessive daytime sleepiness in patients with narcolepsy. Narcolepsy is a lifelong neurological disorder with onset commonly in childhood or adolescence. Sodium oxybate is a metabolite of gamma aminobutyric acid and is approved by the US Food and Drug Administration (FDA) for the treatment of cataplexy and excessive daytime sleepiness in … Xywav is a novel oxybate product with a unique composition of cations, resulting in 92% less sodium than sodium oxybate (Xyrem, Jazz Pharmaceuticals) at the recommended dosage range of 6 … 70% of those users who reviewed Sodium oxybate reported a positive effect, while 15% reported a negative effect. The drug is tightly regulated and only distributed through a restricted program to minimize the risk of misuse, especially among young patients. Sodium Oxybate is currently the only drug approved for the treatment of excessive daytime sleepiness (EDS) and cataplexy in patients suffering from narcolepsy. More recently a series of trials have shown its efficacy in treating narcolepsy: given at night in two doses 3-4 hours apart, sodium oxybate consolidates nocturnal sleep, reduces excessive daytime sleepiness, and often abolishes cataplexy. Sodium Oxybate. Calcium, magnesium, potassium, and sodium oxybate is used to treat attacks of cataplexy (episodes of muscle weakness that begin suddenly and last for a short time) and excessive daytime sleepiness in adults and children 7 years of age and older who have narcolepsy (a sleep disorder that may cause extreme sleepiness, sudden uncontrollable urge to sleep during daily activities, and … Patients and methods: Fifty-five (55) narcoleptic patients with cataplexy who had received continuous treatment with sodium oxybate for 7–44 months (mean 21 months) were enrolled in a double-blind … It is also an effective therapy for disrupted nocturnal sleep. Once-Nightly Sodium Oxybate for Treatment of Excessive Daytime Sleepiness and Cataplexy in Narcolepsy. A quarter of patients experience SEs requiring withdrawal of the drug with older patients being more vulnerable to the more serious SEs. J Clin Sleep Med . Xyrem (sodium oxybate {GHB}) is a sedative that promotes sleep and used for the treatment of narcolepsy to help people sleep better at night and to reduce excessive daytime sleepiness and cataplexy. This drug carries a risk of addiction and abuse, so it's classified as a Schedule III controlled substance. sodium oxybate ( soe -dee-um ox -ee-bate) , Xyrem (trade name), gamma hydroxybutyrate (GHB) (trade name) Classification Therapeutic: anticataplectic Pharmacologic: hydroxybutyrate Pregnancy Category: B Indications Treatment of cataplexy in patients with narcolepsy (generally with concurrent stimulant therapy). Xyrem (sodium oxybate) is a central nervous system depressant that slows down activity in the brain. ... Narcolepsy is a chronic sleep disorder characterized by … Xyrem (sodium oxybate) is a central nervous system depressant drug indicated for the treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy. A Double-blind, Randomized, Placebo Controlled, Two Arm Multi-center Study to Assess the Efficacy and Safety of a Once Nightly Formulation of Sodium Oxybate for Extended-Release Oral Suspension (FT218) for the Treatment of Excessive Daytime Sleepiness and Cataplexy in Subjects With Narcolepsy Oral administration of sodium oxybate to pregnant rats (0, 150, 350, or 1,000 mg/kg/day) or rabbits (0, 300, 600, or 1,200 mg/kg/day) throughout organogenesis produced no clear evidence of developmental toxicity. Avadel Pharmaceuticals plc, a company focused on developing FT218, an investigational, once-nightly formulation of sodium oxybate designed to treat excessive daytime sleepiness and cataplexy in patients with narcolepsy, provided a business update. Sodium oxybate is an orphan drug which was designed specifically for the treatment of narcolepsy. In Trial 3 where sodium oxybate was titrated from an initial 4.5 g per night dose, there was a single event of confusion in one patient at the 9 g per night dose. Resource article. narcolepsy Assuming positive results in the second study, the company anticipates submitting a New Drug Application for sodium oxybate for the treatment of fibromyalgia to the U.S. Food and Drug Administration by the end of 2009." Xyrem (sodium oxybate) and Xywav (calcium, magnesium, potassium, sodium oxybates) are central nervous system depressants indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy. Driving and skilled tasks Leave at least 6 hours between taking sodium oxybate and performing skilled tasks (e.g. Catathrenia is a parasomnia characterized by groaning and an abnormal respiratory pattern during sleep. J Clin Sleep Med . Sodium oxybate improves narcolepsy symptoms and enhances quality of life in narcolepsy … It is used sometimes in France and Italy as an anesthetic given intravenously; it is also used in Italy to treat alcohol addiction and alcohol withdrawal syndrome. While sedatives, such as Ambien or benzodiazepines, help people with insomnia fall asleep, Xyrem is the only medication that effectively produces continuous nighttime sleep for those with narcolepsy. Sodium oxybate and modafinil are both effective for treating excessive daytime sleepiness in narcolepsy, producing additive effects when used together. Sodium oxybate (SO), a first-line treatment of type 1 narcolepsy (NT1), has the ability to improve nocturnal rapid eye movement (REM) sleep behavior disorder (RBD) and REM sleep without atonia (RSWA) in patients with NT1, according to a newly published study. Sodium oxybate is a powerful sedative used to treat cataplexy but can also help with many of the other symptoms of narcolepsy, including excessive daytime sleepiness and sleep paralysis. Sodium oxybate (Xyrem ®, UCB Pharma, Brussels, Belgium) is an efficacious drug for all three symptoms which improves the quality of life of narcoleptic patients. CNS depressants slow down brain activity, which makes them useful for treating sleep disorders. The FDA approved the drug based on a phase 3 trial involving 201 patients who had narcolepsy with cataplexy. Document. It helps with excessive daytime sleepiness as well as helping to control cataplexy. Submitted by: Deborah Profant, PhD Associate Director, Jazz Pharmaceuticals deb.profant@jazzpharma.com Xyrem® (Sodium Oxybate) Oral Solution Executive Summary for Medicaid Narcolepsy Overview Narcolepsy is a chronic neurologic disorder that involves dysregulation of the sleep/wake cycle.1 Narcolepsy is associated with a pentad of symptoms – excessive daytime … JZP-258 is a novel oxybate product candidate with a unique composition of cations. The consistency with which FT218, or once-nightly sodium oxybate, improved both subjective and objective symptoms of narcolepsy – including disturbed nocturnal sleep – … Narcolepsy is a sleep disorder that causes excessive daytime sleepiness. Sodium oxybate is the only medication approved to treat cataplexy in patients with narcolepsy. The present study provided an opportunity to further characterize these sleep-related effects in patients with narcolepsy during treatment with sodium oxybate as monotherapy or in combination with modafinil. Xyrem (sodium oxybate) is one of the only drugs prescribed to treat both the daytime sleepiness and cataplexy of narcolepsy. Sodium oxybate is currently used as a treatment for narcolepsy and has undergone clinical trials to show that it is safe and effective. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. driving or operating machinery); effects of alcohol and other CNS depressants enhanced. Sodium oxybate is the only agent FDA-approved for treating cataplexy—muscle weakness common among patients with narcolepsy. What are the side effects of sodium oxybate (Xyrem)? The consistency with which FT218, or once-nightly sodium oxybate, improved both subjective and objective symptoms of narcolepsy – including disturbed nocturnal sleep – … Drakatos P, Lykouras D, D'Ancona G, et al. Sodium oxybate is primarily used to treat two symptoms of narcolepsy, sudden muscle weakness and excessive daytime sleepiness, by acting as a CNS depressant. Sodium oxybate demonstrates long-term efficacy for the treatment of cataplexy in patients with narcolepsy Sleep Med 2004 511923, 15033130 Google Scholar 22 Black JHoughton WC Sodium oxybate improves excessive daytime sleepiness in narcolepsy Sleep 2006 2993946, 16895262 Sodium oxybate (i.e., GHB) is used recreationally for its ability to induce sedation and euphoria, and it has a high potential for misuse. Nowadays, sodium oxybate is the first-line treatment for narcolepsy and it is highly effective in meliorating sleep architecture, decreasing EDS and the frequency of cataplexy attacks in narcoleptic patients. It helps with excessive daytime sleepiness as well as helping the symptoms of cataplexy. Sodium oxybate is primarily used to treat two symptoms of narcolepsy, sudden muscle weakness and excessive daytime sleepiness, by acting as a CNS depressant. Administration of sodium oxybate presents some practical challenges, including dose titration, twice nightly administration, and need for abstinence from alcohol. Sodium oxybate currently finds also application in the treatment of AWS and the maintenance of alcohol abstinence in alcoholics. Sleep 2002 Feb 1; 25(1): 42–9. Data. Sodium oxybate is often thought of as the most effective treatment for narcolepsy with cataplexy, either on its own or in combination with one or more stimulants. Xyrem is a medication that contains the active ingredient Sodium Oxybate. XYWAV oral solution contains oxybate, a CNS depressant. Cataplexy is a symptom of narcolepsy involving sudden muscle weakness in response to an emotional reaction such as anger, fear, joy, laughter or surprise. Sodium oxybate carries warnings about its high sodium content, 10 and was previously the only product approved to treat both cataplexy and EDS in patients with narcolepsy … Sodium oxybate is a liquid medicine you drink at night in 2 doses: the first when you get into bed, and the second 2.5 to 4 hours later. See what others have said about Xyrem (Sodium Oxybate), including the … BACKGROUND: Previous studies indicate that nightly sodium oxybate administration reduces nocturnal sleep disruption in narcolepsy. Before taking sodium oxybate. healthysleep.med.harvard.edu/narcolepsy/treating-narcolepsy/medications Initial dose: 4.5 g orally per day, divided and given as 2 equal doses with the first dose taken at bedtime and the second dose taken between 2.5 to 4 hours later -The Safety and efficacy of long-term use of sodium oxybate for narcolepsy with cataplexy in routine clinical practice. Sodium oxybate is a powerful sedative that is sold under the brand name Xyrem. On methylphenidate, which increases heart rate, for 27 years, she convinced her Dr to help her get in a sodium oxybate program. 1 The study evaluated 19 children and adolescents with NT1 (mean age, 12.5 [±2.7] years; mean disease duration, 3.4 [±1.6] … Narcolepsy patients may also experience daytime hallucinations unrelated to sleep-wake transitions. JZP-258 is a novel oxybate product candidate with a unique composition of cations resulting in 92% less sodium than Xyrem ® (sodium oxybate). The purpose of this study was to evaluate the effects of sodium oxybate on weight in patients with narcolepsy. Narcolepsy is a sleep disorder that is characterized by excessive daytime sleepiness. Xyrem (Sodium Oxybate) received an overall rating of 8 out of 10 stars from 54 reviews. Each mL of XYWAV contains: 0.234 g calcium oxybate, Ca(C 4 H 7 O 3)2; 0.096 g magnesium oxybate… People with narcolepsy typically use drug therapy for decades. Animal Data. Out of 136 participants, 1 withdrew because of acute confusion and 9 others left because of … Drug interactions of Xyrem include alcohol or sedative hypnotics. Sodium oxybate is used to treat narcolepsy when cataplexy is also a problem. Side effects of Xyrem include: dizziness, nausea, vomiting, diarrhea, or ; … Oxybate has been reported to cause serum enzyme elevations during therapy, but has not been implicated in instances of clinically apparent acute liver injury. Treatment with sodium oxybate in children with type 1 narcolepsy (NT1) is associated with weight reduction that stabilizes after 2 years of therapy, according to study results published in … Cataplexy is found in 75% patients with narcolepsy [5]. Sodium oxybate, a drug approved for narcolepsy, is found to have positive effects on major symptoms of fibromyalgia. This clinical commissioning policy outlines the criteria when we will commission sodium oxybate for symptom control of narcolepsy with cataplexy (children and adolescents, aged 7 until they are 19 years old). •Sodium oxybate is an effective treatment for excessive daytime sleepiness and cataplexy in patients with narcolepsy •The approved effective doses of sodium oxybate are 6, 7.5 and 9 g per night, divided in two doses –the first taken at bedtime and the second 2.5 –4 hours later. A randomized, double blind, placebo-controlled multicenter trial comparing the effects of three doses of orally administered sodium oxybate with placebo for the treatment of narcolepsy. What is sodium oxybate? Sodium oxybate was first approved by the FDA in 2002 to treat cataplexy in adults with narcolepsy and, as reported by Medscape Medical News, was expanded in 2005 to also treat excessive daytime sleepiness (EDS). … Both contain sodium oxybate, a powerful medication that can be habit-forming. Xyrem (sodium oxybate), a central nervous system (CNS) depressant, is a narcolepsy medication that treats narcolepsy symptoms such as cataplexy (or a sudden loss of muscle tone), and excessive daytime sleepiness. Xyrem is used to treat narcolepsy and is a controlled substance due to the potential for abuse and addiction. Sodium oxybate ( Xyrem) is a central nervous system depressant used for the treatment of cataplexy and extreme daytime sleepiness (EDS) associated with narcolepsy. It is the sodium salt of gamma hydroxybutyric acid (GHB) which is an endogenous compound and a metabolite of the neurotransmitter GABA. Sodium oxybate is also known as GHB, a known street drug of abuse. Sodium oxybate has been well tolerated in relatively small clinical trials. In the majority of cases in all adult clinical trials in patients with narcolepsy, confusion resolved either soon … sodium oxybate for narcolepsy. Because of … Narcolepsy patients started SXB treatment after completion of the first clamp session. 80 The first one was used in its FDA approval. XYWAV™ (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is a prescription medicine used to treat the following symptoms in people 7 years of age or older with narcolepsy: sudden onset of weak or paralyzed muscles (cataplexy) excessive daytime sleepiness (EDS) US Xyrem® Multicenter Study Group. Sodium oxybate in a dose of 6–9 g was indicated in patients with narcolepsy-cataplexy syndrome according to the frequency of symptoms and the appearance of adverse effects. Sodium oxybate is a metabolite of gamma aminobutyric acid and is approved by the US Food and Drug Administration (FDA) for the treatment of cataplexy and excessive daytime sleepiness in … Sodium oxybate has efficacy in many narcolepsy symptoms. The effectiveness of sodium oxybate for the treatment of narcolepsy symptoms was established in four multicentre, randomised, double-blind, placebo-controlled, parallel-group trials (Trial 1, 2, 3 and 4) in patients with narcolepsy with cataplexy except for … Our Controlled Substance and API portfolio is supported by a global network of GMP facilities: West Deptford, NJ; Devens, MA; North Andover, MA; Edinburgh, UK and Annan, UK. Sodium oxybate carries warnings about its high sodium content, 10 and was previously the only product approved to treat both cataplexy and EDS in patients with narcolepsy … Sodium oxybate is also known as GHB, a known street drug of abuse. Sodium oxybate is often thought of as the most effective treatment for narcolepsy with cataplexy, either on its own or in combination with one or more stimulants. However, not all patients find it beneficial. SIDE-EFFECTS - As with any medication, the drugs used to treat narcolepsy can have side-effects. These can take many forms. The study will take place over 17 weeks. Patient should not have taken sodium oxybate for more than 2 weeks; c. All previous dosing must not have occurred within the last year prior to … 2 Epidemiology Narcolepsy is a lifelong disorder. The nightly use of sodium oxybate is associated with a reduction in nocturnal sleep disruption: a double-blind, placebo-controlled study in patients with narcolepsy. Sodium oxybate and modafinil are both effective for treating excessive daytime sleepiness in narcolepsy, producing additive effects when used together. Demanding that a patient’s need is “exceptional” is irrational and should be abandoned Narcolepsy affects around 4 in 10 000 people, making it about one quarter as common as multiple sclerosis in the United Kingdom.1 Its cardinal features are excessive daytime sleepiness causing frequent, irresistible naps; cataplexy, leading to collapse, embarrassment, and sometimes injury; and … Patients or carers should be given advice on how to administer sodium oxybate oral solution. In clinical trials at recommended doses, obtundation and clinically significant respiratory depression occurred in XYREM-treated patients. Sodium oxybate is the active ingredient in the narcolepsy drug Xyrem, which has been studied for fibromyalgia (FMS) and is sometimes used off-label for FMS and chronic fatigue syndrome . PURPOSE: This study aims to report on catathrenia occurring in narcolepsy with cataplexy (NC) patients under sodium oxybate (SO) treatment. Xyrem (sodium oxybate) oral solution is indicated for the treatment of cataplexy in narcolepsy. Xyrem (sodium oxybate) oral solution is indicated for the treatment of excessive daytime sleepiness (EDS) in narcolepsy. What are the side effects of sodium oxybate (Xyrem)? Xyrem (sodium oxybate) is a CNS depressant. Sodium oxybate promotes deep sleep and improves night-time sleep. This clinical research study is being done to measure the safety and effectiveness of the new extended-release formulation of sodium oxybate. It is approved for use in people with narcolepsy ages 7 and older. Kovacević-Ristanović R, Kuźniar TJ (2010) Use of sodium effects in most of our patients (28/51, 54.9%), but a oxybate (Xyrem) in patients with dual diagnosis of narcolepsy and sleep apnea. AIM: To present the characteristics of sodium oxybate, a new drug that has been approved in the United States and in the European Union for use in treating narcolepsy-cataplexy; the main contribution made by this new agent is the possibility of acting on all the symptoms of the disease at the same time. CONCLUSIONS: Sodium oxybate provides a good clinical efficacy and acceptable safety profile in routine clinical practice for the treatment of patients suffering from narcolepsy with cataplexy. Sodium oxy dosage increased per instructions over time, had delusional, withdrawn effects and slowed speech. Sodium oxybate. Sleep Med 11:5–6 spontaneous resolution was observed in many of them (19/ 15. Sodium oxybate is a medicine that can improve sudden loss of muscle control and help you sleep at night, which can also reduce daytime sleepiness. Subsequent effects of sodium oxybate on later growth, development, and maturation in humans are unknown. excessive daytime sleepiness in adults and children 7 years of age and older The prevalence of narcolepsy with … XYWAV provides a lower-sodium oxybate treatment option than sodium oxybate. “Lower-sodium oxybate (LXB) has 92% less sodium than sodium oxybate and is approved in the United States for the treatment of cataplexy or excessive daytime sleepiness in … Our Controlled Substance and API portfolio is supported by a global network of GMP facilities: West Deptford, NJ; Devens, MA; North Andover, MA; Edinburgh, UK and Annan, UK. Xywav is a novel oxybate product with a unique composition of cations, resulting in 92% less sodium than sodium oxybate (Xyrem, Jazz Pharmaceuticals) at the recommended dosage range of 6 to 9 grams, the company said in a news release. Sodium oxybate is beneficial as both monotherapy and as adjunctive therapy for the treatment of excessive daytime sleepiness in narcolepsy. Subsequently, the dose was titrated up to an optimum for each individual patient, although never exceeded the maximum dose of 9 grams per night. Sodium oxybate is used to treat cataplexy but can also help with many of the other symptoms of narcolepsy. Sodium oxybate (SXB) is a sodium salt of γ‐hydroxybutyrate, an endogenous metabolite of γ‐aminobutyric acid (GABA); SXB is approved for the treatment of excessive daytime sleepiness (EDS) in narcolepsy and for the treatment of cataplexy in narcolepsy [Xyrem; Xyrem ® (sodium oxybate… METHODS: Charts from three centers of all patients with narcolepsy who had been using sodium oxybate for at least 3 … XYWAV TM (calcium, magnesium, potassium, and sodium oxybates) oral solution, 0.5 g/mL total salts (equivalent to 0.413 g/mL of oxybate) is indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients 7 years of age and older with narcolepsy. sodium oxybate for narcolepsy. What Is Sodium Oxybate Sodium oxybate is an active ingredient in Xyrem, a drug approved by the FDA for the treatment in adult patients with narcolepsy and cataplexy. In the 4-week, placebo-controlled trial, 3 nausea, headache, dizziness, and enuresis were most frequently reported. Sodium oxybate (Xyrem) is the sodium salt of a compound, γ-hydroxybutyric acid (GHB), which serves as a precursor of the neurotransmitter γ-aminobutyric acid (GABA) along with possessing neuromodulator properties, and is involved in sleep regulation .
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